Ontology highlight
ABSTRACT:
SUBMITTER: Blekhman R
PROVIDER: S-EPMC2581600 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Blekhman Ran R Oshlack Alicia A Chabot Adrien E AE Smyth Gordon K GK Gilad Yoav Y
PLoS genetics 20081121 11
Regulatory changes have long been hypothesized to play an important role in primate evolution. To identify adaptive regulatory changes in humans, we performed a genome-wide survey for genes in which regulation has likely evolved under natural selection. To do so, we used a multi-species microarray to measure gene expression levels in livers, kidneys, and hearts from six humans, chimpanzees, and rhesus macaques. This comparative gene expression data allowed us to identify a large number of genes, ...[more]