Ontology highlight
ABSTRACT:
SUBMITTER: Sonawane AR
PROVIDER: S-EPMC5828531 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Sonawane Abhijeet Rajendra AR Platig John J Fagny Maud M Chen Cho-Yi CY Paulson Joseph Nathaniel JN Lopes-Ramos Camila Miranda CM DeMeo Dawn Lisa DL Quackenbush John J Glass Kimberly K Kuijjer Marieke Lydia ML
Cell reports 20171001 4
Although all human tissues carry out common processes, tissues are distinguished by gene expression patterns, implying that distinct regulatory programs control tissue specificity. In this study, we investigate gene expression and regulation across 38 tissues profiled in the Genotype-Tissue Expression project. We find that network edges (transcription factor to target gene connections) have higher tissue specificity than network nodes (genes) and that regulating nodes (transcription factors) are ...[more]