Ontology highlight
ABSTRACT:
SUBMITTER: Epsztejn-Litman S
PROVIDER: S-EPMC2581722 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Epsztejn-Litman Silvina S Feldman Nirit N Abu-Remaileh Monther M Shufaro Yoel Y Gerson Ariela A Ueda Jun J Deplus Rachel R Fuks François F Shinkai Yoichi Y Cedar Howard H Bergman Yehudit Y
Nature structural & molecular biology 20081026 11
The pluripotency-determining gene Oct3/4 (also called Pou5f1) undergoes postimplantation silencing in a process mediated by the histone methyltransferase G9a. Microarray analysis now shows that this enzyme may operate as a master regulator that inactivates numerous early-embryonic genes by bringing about heterochromatinization of methylated histone H3K9 and de novo DNA methylation. Genetic studies in differentiating embryonic stem cells demonstrate that a point mutation in the G9a SET domain pre ...[more]