Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC2581985 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Wang Hongsheng H Lee Chang Hoon CH Qi Chenfeng C Tailor Prafullakumar P Feng Jianxun J Abbasi Sadia S Atsumi Toru T Morse Herbert C HC
Blood 20080917 10
PU.1, IKAROS, E2A, EBF, and PAX5 comprise a transcriptional network that orchestrates B-cell lineage specification, commitment, and differentiation. Here we identify interferon regulatory factor 8 (IRF8) as another component of this complex, and show that it also modulates lineage choice by hematopoietic stem cells (HSCs). IRF8 binds directly to an IRF8/Ets consensus sequence located in promoter regions of Sfpi1 and Ebf1, which encode PU.1 and EBF, respectively, and is associated with transcript ...[more]