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PTPN2 regulates T cell lineage commitment and ?? versus ?? specification.

ABSTRACT: In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted ?? T cell receptor (TCR) T cells and non-MHC-restricted ?? TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into ?? TCR versus ?? TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate ?? TCR versus ?? TCR T cell development. Our findings identify PTPN2 as an important regulator of critical checkpoints that dictate the commitment of multipotent precursors to the T cell lineage and their subsequent maturation into ?? TCR or ?? TCR T cells.

SUBMITTER: Wiede F

PROVIDER: S-EPMC5584121 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.

Wiede Florian F Dudakov Jarrod A JA Lu Kun-Hui KH Dodd Garron T GT Butt Tariq T Godfrey Dale I DI Strasser Andreas A Boyd Richard L RL Tiganis Tony T

The Journal of experimental medicine 20170810 9

In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted αβ T cell receptor (TCR) T cells and non-MHC-restricted γδ TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into αβ TCR versus γδ TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal tra ...[more]

PMID: 28798028

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