Ontology highlight
ABSTRACT:
SUBMITTER: Ohrt T
PROVIDER: S-EPMC2582625 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Ohrt Thomas T Mütze Jörg J Staroske Wolfgang W Weinmann Lasse L Höck Julia J Crell Karin K Meister Gunter G Schwille Petra P
Nucleic acids research 20081008 20
Studies of RNA interference (RNAi) provide evidence that in addition to the well-characterized cytoplasmic mechanisms, nuclear mechanisms also exist. The mechanism by which the nuclear RNA-induced silencing complex (RISC) is formed in mammalian cells, as well as the relationship between the RNA silencing pathways in nuclear and cytoplasmic compartments is still unknown. Here we show by applying fluorescence correlation and cross-correlation spectroscopy (FCS/FCCS) in vivo that two distinct RISC ...[more]