Ontology highlight
ABSTRACT:
SUBMITTER: Zikova A
PROVIDER: S-EPMC2583542 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Zíková Alena A Panigrahi Aswini K AK Uboldi Alessandro D AD Dalley Rachel A RA Handman Emanuela E Stuart Kenneth K
Eukaryotic cell 20080905 11
A mitochondrial inner membrane protein, designated MIX, seems to be essential for cell viability. The deletion of both alleles was not possible, and the deletion of a single allele led to a loss of virulence and aberrant mitochondrial segregation and cell division in Leishmania major. However, the mechanism by which MIX exerts its effect has not been determined. We show here that MIX is also expressed in the mitochondrion of Trypanosoma brucei, and using RNA interference, we found that its loss ...[more]