African trypanosomes contain 5-methylcytosine in nuclear DNA.
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ABSTRACT:
SUBMITTER: Militello KT
PROVIDER: S-EPMC2583544 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
African trypanosomes contain 5-methylcytosine in nuclear DNA.
Militello Kevin T KT Wang Ping P Jayakar Sangeeta K SK Pietrasik Rebecca L RL Dupont Christopher D CD Dodd Kristi K King Anthony M AM Valenti Paul R PR
Eukaryotic cell 20080912 11
It is currently unclear if there are modified DNA bases in Trypanosoma brucei other than J-base. We identify herein a cytosine-5 DNA methyltransferase gene and report the presence and location of 5-methylcytosine in genomic DNA. Our data demonstrate that African trypanosomes contain a functional cytosine DNA methylation pathway. ...[more]
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