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Comment on "Differential rescue of light- and food-entrainable circadian rhythms".

ABSTRACT: Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1-/- mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions.

SUBMITTER: Mistlberger RE

PROVIDER: S-EPMC2583785 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Comment on "Differential rescue of light- and food-entrainable circadian rhythms".

Mistlberger Ralph E RE Yamazaki Shin S Pendergast Julie S JS Landry Glenn J GJ Takumi Toru T Nakamura Wataru W

Science (New York, N.Y.) 20081001 5902

Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1-/- mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions. ...[more]

PMID: 18974333

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