Comment on "Circadian rhythms in the absence of the clock gene Bmal1".
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ABSTRACT:
SUBMITTER: Ness-Cohn E
PROVIDER: S-EPMC9172996 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Comment on "Circadian rhythms in the absence of the clock gene <i>Bmal1</i>".
Ness-Cohn Elan E Allada Ravi R Braun Rosemary R
Science (New York, N.Y.) 20210401 6539
Ray <i>et al</i> (Reports, 14 February 2020, p. 800) report apparent transcriptional circadian rhythms in mouse tissues lacking the core clock component BMAL1. To better understand these surprising results, we reanalyzed the associated data. We were unable to reproduce the original findings, nor could we identify reliably cycling genes. We conclude that there is insufficient evidence to support circadian transcriptional rhythms in the absence of <i>Bmal1</i>. ...[more]
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