Ontology highlight
ABSTRACT:
SUBMITTER: Lavender V
PROVIDER: S-EPMC2584333 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Lavender Verna V Chong Setareh S Ralphs Katherine K Wolstenholme Adrian J AJ Reaves Barbara J BJ
The Biochemical journal 20080801 3
The hTRPC [human TRPC (canonical transient receptor potential)] family of non-selective cation channels is proposed to mediate calcium influx across the plasma membrane via PLC (phospholipase C)-coupled receptors. Heterologously expressed hTRPC3 and hTRPC7 have been localized at the cell surface; however, a large intracellular component has also been noted but not characterized. In the present study, we have investigated the intracellular pool in COS-7 cells and have shown co-localization with m ...[more]