Ontology highlight
ABSTRACT:
SUBMITTER: Schlieker CD
PROVIDER: S-EPMC2584574 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Schlieker Christian D CD Van der Veen Annemarthe G AG Damon Jadyn R JR Spooner Eric E Ploegh Hidde L HL
Proceedings of the National Academy of Sciences of the United States of America 20081118 47
Urm1 is a highly conserved ubiquitin-related modifier of unknown function. A reduction of cellular Urm1 levels causes severe cytokinesis defects in HeLa cells, resulting in the accumulation of enlarged multinucleated cells. To understand the underlying mechanism, we applied a functional proteomics approach and discovered an enzymatic activity that links Urm1 to a tRNA modification pathway. Unlike ubiquitin (Ub) and many Ub-like modifiers, which are commonly conjugated to proteinaceous targets, U ...[more]