Ontology highlight
ABSTRACT:
SUBMITTER: Penn AC
PROVIDER: S-EPMC2585171 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
The EMBO journal 20081016 22
Ion channel biogenesis involves an intricate interplay between subunit folding and assembly. Channel stoichiometries vary and give rise to diverse functions, which impacts on neuronal signalling. AMPA glutamate receptor (AMPAR) assembly is modulated by RNA processing. Here, we provide mechanistic insight into this process. First, we show that a single alternatively spliced residue within the ligand-binding domain alters AMPAR secretion from the ER. Local contacts differ between Leu758 of the Glu ...[more]