Ontology highlight
ABSTRACT:
SUBMITTER: Han GM
PROVIDER: S-EPMC2585376 | biostudies-literature | 2008 May-Jun
REPOSITORIES: biostudies-literature
Han Guang Ming GM O'Neil-Andersen Nancy J NJ Zurier Robert B RB Lawrence David A DA
Cellular immunology 20080501 1-2
Accumulating evidences support that CD4(+)CD25(high) T regulatory (Treg) cells play an essential role in controlling and preventing autoimmunity. Paradoxically, RA patients have elevated numbers of circulating CD4(+)CD25(high) T cells, however, the inflammation is still ongoing. Further identification of these CD4(+)CD25(high) T cells may contribute to a better understanding of underlying mechanisms. We show here that these CD4(+)CD25(high) T cells were composed of CD4(+)CD25(high)FoxP3(+) Treg ...[more]