Ontology highlight
ABSTRACT:
SUBMITTER: Marson A
PROVIDER: S-EPMC2586071 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Marson Alexander A Levine Stuart S SS Cole Megan F MF Frampton Garrett M GM Brambrink Tobias T Johnstone Sarah S Guenther Matthew G MG Johnston Wendy K WK Wernig Marius M Newman Jamie J Calabrese J Mauro JM Dennis Lucas M LM Volkert Thomas L TL Gupta Sumeet S Love Jennifer J Hannett Nancy N Sharp Phillip A PA Bartel David P DP Jaenisch Rudolf R Young Richard A RA
Cell 20080801 3
MicroRNAs (miRNAs) are crucial for normal embryonic stem (ES) cell self-renewal and cellular differentiation, but how miRNA gene expression is controlled by the key transcriptional regulators of ES cells has not been established. We describe here the transcriptional regulatory circuitry of ES cells that incorporates protein-coding and miRNA genes based on high-resolution ChIP-seq data, systematic identification of miRNA promoters, and quantitative sequencing of short transcripts in multiple cell ...[more]