Ontology highlight
ABSTRACT:
SUBMITTER: Akhmedov NB
PROVIDER: S-EPMC25866 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
Akhmedov N B NB Piriev N I NI Chang B B Rapoport A L AL Hawes N L NL Nishina P M PM Nusinowitz S S Heckenlively J R JR Roderick T H TH Kozak C A CA Danciger M M Davisson M T MT Farber D B DB
Proceedings of the National Academy of Sciences of the United States of America 20000501 10
The rd7 mouse, an animal model for hereditary retinal degeneration, has some characteristics similar to human flecked retinal disorders. Here we report the identification of a deletion in a photoreceptor-specific nuclear receptor (mPNR) mRNA that is responsible for hereditary retinal dysplasia and degeneration in the rd7 mouse. mPNR was isolated from a pool of photoreceptor-specific cDNAs originally created by subtractive hybridization of mRNAs from normal and photoreceptorless rd mouse retinas. ...[more]