Ontology highlight
ABSTRACT:
SUBMITTER: Calzolari F
PROVIDER: S-EPMC2586688 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Calzolari Filippo F Appolloni Irene I Tutucci Evelina E Caviglia Sara S Terrile Marta M Corte Giorgio G Malatesta Paolo P
Neoplasia (New York, N.Y.) 20081201 12
Platelet-derived growth factor B (PDGF-B) overexpression induces gliomas of different grades from murine embryonic neural progenitors. For the first time, we formally demonstrated that PDGF-B-induced neoplasms undergo progression from nontumorigenic low-grade tumors toward highly malignant forms. This result, showing that PDGF-B signaling alone is insufficient to confer malignancy to cells, entails the requirement for further molecular lesions in this process. Our results indicate that one of th ...[more]