Ontology highlight
ABSTRACT:
SUBMITTER: Appolloni I
PROVIDER: S-EPMC3509603 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Appolloni Irene I Curreli Sebastiano S Caviglia Sara S Barilari Manuela M Gambini Eleonora E Pagano Aldo A Malatesta Paolo P
International journal of molecular sciences 20121112 11
Tumor progression is a key aspect in oncology. Not even the overexpression of a powerful oncogenic stimulus such as platelet derived growth factor-B (PDGF-B) is sufficient per se to confer full malignancy to cells. In previous studies we showed that neural progenitors overexpressing PDGF-B need to undergo progression to acquire the capability to give rise to secondary tumor following transplant. By comparing the expression profile of PDGF-expressing cells before and after progression, we found t ...[more]