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Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications.

ABSTRACT: We have developed a versatile nanoparticle construct using a compact cysteine coating on a CdSe(ZnCdS) core(shell) nanocrystal (QD-Cys) that is biologically compatible, exceptionally compact, highly fluorescent, and easily functionalized. The small hydrodynamic diameter of QD-Cys ( approximately 6 nm) allows for renal clearance of these nanoparticles in rat models. Moreover, the ability to directly conjugate to QD-Cys opens up the possibility of functionalized nanocrystals for in vivo targeted imaging, in which small targeting molecules can be appended to QD-Cys, and unbound QDs can be rapidly cleared to achieve high signal/noise ratios and to reduce background toxicity.

SUBMITTER: Liu W

PROVIDER: S-EPMC2587328 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature

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Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications.

Liu Wenhao W Choi Hak Soo HS Zimmer John P JP Tanaka Eiichi E Frangioni John V JV Bawendi Moungi M

Journal of the American Chemical Society 20071106 47

We have developed a versatile nanoparticle construct using a compact cysteine coating on a CdSe(ZnCdS) core(shell) nanocrystal (QD-Cys) that is biologically compatible, exceptionally compact, highly fluorescent, and easily functionalized. The small hydrodynamic diameter of QD-Cys ( approximately 6 nm) allows for renal clearance of these nanoparticles in rat models. Moreover, the ability to directly conjugate to QD-Cys opens up the possibility of functionalized nanocrystals for in vivo targeted i ...[more]

PMID: 17983223

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