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InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.

ABSTRACT: We present the synthesis of InAs quantum dots (QDs) with a ZnCdS shell with bright and stable emission in the near-infrared (NIR, 700-900 nm) region for biological imaging applications. We demonstrate how NIR QDs can image tumor vasculature in vivo at significantly deeper penetration depths and with higher contrast than visible emitting CdSe(CdS) QDs. Targeted cellular labeling is also presented and may enable multiplexed and low autofluorescence cellular imaging.

SUBMITTER: Allen PM 

PROVIDER: S-EPMC2862004 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.

Allen Peter M PM   Liu Wenhao W   Chauhan Vikash P VP   Lee Jungmin J   Ting Alice Y AY   Fukumura Dai D   Jain Rakesh K RK   Bawendi Moungi G MG  

Journal of the American Chemical Society 20100101 2

We present the synthesis of InAs quantum dots (QDs) with a ZnCdS shell with bright and stable emission in the near-infrared (NIR, 700-900 nm) region for biological imaging applications. We demonstrate how NIR QDs can image tumor vasculature in vivo at significantly deeper penetration depths and with higher contrast than visible emitting CdSe(CdS) QDs. Targeted cellular labeling is also presented and may enable multiplexed and low autofluorescence cellular imaging. ...[more]

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