Cardiac myosin-binding protein C decorates F-actin: implications for cardiac function.
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ABSTRACT:
SUBMITTER: Whitten AE
PROVIDER: S-EPMC2587536 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Cardiac myosin-binding protein C decorates F-actin: implications for cardiac function.
Whitten Andrew E AE Jeffries Cy M CM Harris Samantha P SP Trewhella Jill J
Proceedings of the National Academy of Sciences of the United States of America 20081114 47
Cardiac myosin-binding protein C (cMyBP-C) is an accessory protein of striated muscle sarcomeres that is vital for maintaining regular heart function. Its 4 N-terminal regulatory domains, C0-C1-m-C2 (C0C2), influence actin and myosin interactions, the basic contractile proteins of muscle. Using neutron contrast variation data, we have determined that C0C2 forms a repeating assembly with filamentous actin, where the C0 and C1 domains of C0C2 attach near the DNase I-binding loop and subdomain 1 of ...[more]
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2021-03-23 | GSE169340 | GEO
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