Ontology highlight
ABSTRACT:
SUBMITTER: Rahmanseresht S
PROVIDER: S-EPMC7852460 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Rahmanseresht Sheema S Lee Kyoung H KH O'Leary Thomas S TS McNamara James W JW Sadayappan Sakthivel S Robbins Jeffrey J Warshaw David M DM Craig Roger R Previs Michael J MJ
The Journal of general physiology 20210301 3
Myosin and actin filaments are highly organized within muscle sarcomeres. Myosin-binding protein C (MyBP-C) is a flexible, rod-like protein located within the C-zone of the sarcomere. The C-terminal domain of MyBP-C is tethered to the myosin filament backbone, and the N-terminal domains are postulated to interact with actin and/or the myosin head to modulate filament sliding. To define where the N-terminal domains of MyBP-C are localized in the sarcomere of active and relaxed mouse myocardium, t ...[more]