Ontology highlight
ABSTRACT:
SUBMITTER: Johnson CH
PROVIDER: S-EPMC2588432 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20081001 5902
An endogenous circadian system in cyanobacteria exerts pervasive control over cellular processes, including global gene expression. Indeed, the entire chromosome undergoes daily cycles of topological changes and compaction. The biochemical machinery underlying a circadian oscillator can be reconstituted in vitro with just three cyanobacterial proteins, KaiA, KaiB, and KaiC. These proteins interact to promote conformational changes and phosphorylation events that determine the phase of the in vit ...[more]