Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC2590637 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Liu Zijing Z Li Hong H Hu Xuemei X Yu Ling L Liu Hongbin H Han Ruifa R Colella Rita R Mower George D GD Chen Yiping Y Qiu Mengsheng M
The Journal of neuroscience : the official journal of the Society for Neuroscience 20081001 40
The rhombic lip (RL) is the neuroepithelium immediately adjacent to the roof plate of the fourth ventricle, and it gives rise to various brainstem and cerebellar cell types. Our study shows that the bHLH (basic helix-loop-helix) transcription factor Olig3 is expressed in the progenitors of RL, and ablation of Olig3 significantly affects the development of RL. In Olig3-/- caudal RL, the expression level of Math1 in the dorsal interneuron 1 (dI1) domain is reduced, and the formation of four mossy- ...[more]