Ontology highlight
ABSTRACT:
SUBMITTER: Fujita T
PROVIDER: S-EPMC2592668 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Fujita Takeo T Epperly Michael W MW Zou Hui H Greenberger Joel S JS Wan Yong Y
Molecular biology of the cell 20081008 12
Alteration of the tumor microenvironment by aberrant stromal cells influences many aspects of cell biology, including differentiation of stem cells and tumor metastasis. The role of transforming growth factor (TGF)-beta signaling in stromal cells of the tissue microenvironment is critical to both pathways. We examined murine marrow stromal cells with deletion of Smad3 and found that they have an altered cell cycle profile, with a higher fraction of cells in G2/M phase. Deletion of Smad3 signific ...[more]