Ontology highlight
ABSTRACT:
SUBMITTER: Herzog F
PROVIDER: S-EPMC2989460 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20090301 5920
Once all chromosomes are connected to the mitotic spindle (bioriented), anaphase is initiated by the protein ubiquitylation activity of the anaphase-promoting complex/cyclosome (APC/C) and its coactivator Cdc20 (APC/C(Cdc20)). Before chromosome biorientation, anaphase is delayed by a mitotic checkpoint complex (MCC) that inhibits APC/C(Cdc20). We used single-particle electron microscopy to obtain three-dimensional models of human APC/C in various functional states: bound to MCC, to Cdc20, or to ...[more]