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Genetic studies in osteoporosis--the end of the beginning.

ABSTRACT: Osteoporosis and disorders of bone fragility are highly heritable, but despite much effort the identities of few of the genes involved has been established. Recent developments in genetics such as genome-wide association studies are revolutionizing research in this field, and it is likely that further contributions will be made through application of next-generation sequencing technologies, analysis of copy number variation polymorphisms, and high-throughput mouse mutagenesis programs. This article outlines what we know about osteoporosis genetics to date and the probable future directions of research in this field.

SUBMITTER: Duncan EL

PROVIDER: S-EPMC2592817 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature

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Genetic studies in osteoporosis--the end of the beginning.

Duncan Emma L EL Brown Matthew A MA

Arthritis research & therapy 20080912 5

Osteoporosis and disorders of bone fragility are highly heritable, but despite much effort the identities of few of the genes involved has been established. Recent developments in genetics such as genome-wide association studies are revolutionizing research in this field, and it is likely that further contributions will be made through application of next-generation sequencing technologies, analysis of copy number variation polymorphisms, and high-throughput mouse mutagenesis programs. This arti ...[more]

PMID: 18828878

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Genetic studies in osteoporosis--the end of the beginning.

Publications

Genetic studies in osteoporosis--the end of the beginning.

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