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Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteria.

ABSTRACT: Tet 42, a novel tetracycline resistance determinant from deep subsurface bacteria, was characterized and found to have a 30% sequence similarity to TetA(Z). The protein is a putative efflux pump that shares characteristics with previously characterized pumps, including a divergently transcribed TetR repressor, a conserved GxxSDRxGRR motif, and transmembrane domains.

SUBMITTER: Brown MG

PROVIDER: S-EPMC2592862 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature

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Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteria.

Brown Mindy G MG Mitchell Elizabeth H EH Balkwill David L DL

Antimicrobial agents and chemotherapy 20080922 12

Tet 42, a novel tetracycline resistance determinant from deep subsurface bacteria, was characterized and found to have a 30% sequence similarity to TetA(Z). The protein is a putative efflux pump that shares characteristics with previously characterized pumps, including a divergently transcribed TetR repressor, a conserved GxxSDRxGRR motif, and transmembrane domains. ...[more]

PMID: 18809935

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