Ontology highlight
ABSTRACT:
SUBMITTER: Lebreton S
PROVIDER: S-EPMC2593418 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Lebreton Sylvain S Jaunbergs Janis J Roth Michael G MG Ferguson Deborah A DA De Brabander Jef K JK
Bioorganic & medicinal chemistry letters 20080705 22
The natural product salicylihalamide is a potent inhibitor of the Vacuolar ATPase (V-ATPase), a potential target for antitumor chemotherapy. We generated salicylihalamide-resistant tumor cell lines typified by an overexpansion of lysosomal organelles. We also found that many tumor cell lines upregulate tissue-specific plasmalemmal V-ATPases, and hypothesize that tumors that derive their energy from glycolysis rely on these isoforms to maintain a neutral cytosolic pH. To further validate the pote ...[more]