Ontology highlight
ABSTRACT:
SUBMITTER: D'Andrea F
PROVIDER: S-EPMC6804087 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
D'Andrea Felicia F Vagelli Giulia G Granchi Carlotta C Guazzelli Lorenzo L Tuccinardi Tiziano T Poli Giulio G Iacopini Dalila D Minutolo Filippo F Di Bussolo Valeria V
Molecules (Basel, Switzerland) 20190928 19
Conjugation of known biologically active molecules to carbohydrate frameworks represents a valuable option for the preparation of hybrid, structurally-related families of compounds with the aim of modulating their biological response. Therefore, we present here a study on the preparation of d-<i>galacto</i>, d-<i>manno</i>, d-<i>gluco</i>, and d-<i>lactose</i> glycoconjugates of an established <i>N</i>-hydroxyindole-based (NHI) inhibitor of lactated dehydrogenase (LDH). Structural variations inv ...[more]