Ontology highlight
ABSTRACT:
SUBMITTER: Lanman BA
PROVIDER: S-EPMC2593883 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20070929 42
Hexacyclic congeners 3 and 4 of palau'amine, which incorporate both guanidine functional groups and have the cis configuration of the azabicyclo[3.3.0]octane core, are prepared in 14 steps from cycloadduct 6. Synthetic access to these analogues allows the first direct comparison of NMR data for hexacyclic diguanidine structures having the originally proposed cis-azabicyclo[3.3.0]octane fragment with data for natural alkaloids of the palau'amine family. This comparison provides convincing evidenc ...[more]