Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC2888864 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Li Qingyi Q Hurley Paul P Ding Hui H Roberts Andrew G AG Akella Radha R Harran Patrick G PG
The Journal of organic chemistry 20090801 16
A synthetic approach to palau'amine is described that exploits veiled symmetry in the structure. Bis-alkylidenes i have been prepared and found susceptible to halogenative desymmetrization using t-BuOCl. This oxidation forms the imbedded spirocyclopentane motif observed in the natural product. A host of atypical reactions and processes developed during these studies are discussed, as are plans for completing total syntheses of this compound class. ...[more]