Ontology highlight
ABSTRACT:
SUBMITTER: Inceoglu B
PROVIDER: S-EPMC2596245 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Inceoglu Bora B Jinks Steven L SL Ulu Arzu A Hegedus Christine M CM Georgi Katrin K Schmelzer Kara R KR Wagner Karen K Jones Paul D PD Morisseau Christophe C Hammock Bruce D BD
Proceedings of the National Academy of Sciences of the United States of America 20081121 48
During inflammation, a large amount of arachidonic acid (AA) is released into the cellular milieu and cyclooxygenase enzymes convert this AA to prostaglandins that in turn sensitize pain pathways. However, AA is also converted to natural epoxyeicosatrienoic acids (EETs) by cytochrome P450 enzymes. EET levels are typically regulated by soluble epoxide hydrolase (sEH), the major enzyme degrading EETs. Here we demonstrate that EETs or inhibition of sEH lead to antihyperalgesia by at least 2 spinal ...[more]