Ontology highlight
ABSTRACT:
SUBMITTER: Choi H
PROVIDER: S-EPMC2596341 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Choi Hyungwon H Fermin Damian D Nesvizhskii Alexey I AI
Molecular & cellular proteomics : MCP 20080720 12
Spectral counting has become a commonly used approach for measuring protein abundance in label-free shotgun proteomics. At the same time, the development of data analysis methods has lagged behind. Currently most studies utilizing spectral counts rely on simple data transforms and posthoc corrections of conventional signal-to-noise ratio statistics. However, these adjustments can neither handle the bias toward high abundance proteins nor deal with the drawbacks due to the limited number of repli ...[more]