Ontology highlight
ABSTRACT:
SUBMITTER: Davis AM
PROVIDER: S-EPMC2596627 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Davis Ann M AM Ramos Hilario J HJ Davis Laurie S LS Farrar J David JD
Journal of immunology (Baltimore, Md. : 1950) 20081201 12
IL-2 is a hallmark cytokine secreted by central memory CD4(+) T cells (T(CM)). Although naive cells rapidly secrete IL-2 in response to Ag stimulation, IL-12 inhibits IL-2 secretion in daughter cells as they differentiate into Th1 cells. In this study, we uncover a unique role for IFN-alpha in regulating IL-2 secretion by human T(CM) cells. IFN-alpha synergized with IL-12 to enhance a subset of cells that secreted high and sustained levels of IL-2. These IL-2-secreting cells displayed phenotypic ...[more]