Ontology highlight
ABSTRACT:
SUBMITTER: Schulman BR
PROVIDER: S-EPMC2596717 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Schulman Betsy R Maller BR Esquela-Kerscher Aurora A Slack Frank J FJ
Developmental dynamics : an official publication of the American Association of Anatomists 20051201 4
In C. elegans, heterochronic genes control the timing of cell fate determination during development. Two heterochronic genes, let-7 and lin-4, encode microRNAs (miRNAs) that down-regulate a third heterochronic gene lin-41 by binding to complementary sites in its 3'UTR. let-7 and lin-4 are conserved in mammals. Here we report the cloning and sequencing of mammalian lin-41 orthologs. We find that mouse and human lin-41 genes contain predicted conserved complementary sites for let-7 and the lin-4 o ...[more]