Dataset Information

Expression pattern of protein kinase C ? during mouse embryogenesis.

ABSTRACT:

Background

Protein kinase C epsilon (PKC?) belongs to the novel PKC subfamily, which consists of diacylglycerol dependent- and calcium independent-PKCs. Previous studies have shown that PKC? is important in different contexts, such as wound healing or cancer. In this study, we contribute to expand the knowledge on PKC? by reporting its expression pattern during murine midgestation using the LacZ reporter gene and immunostaining procedures.

Results

Sites showing highest PKC? expression were heart at ealier stages, and ganglia in older embryos. Other stained domains included somites, bone, stomach, kidney, and blood vessels.

Conclusions

The seemingly strong expression of PKC? in heart and ganglia shown in this study suggests a important role of this isoform in the vascular and nervous systems during mouse development. However, functional redundancy with other PKCs during midgestation within these domains and others reported here possibly exists since PKC? deficient mice do not display obvious embryonic developmental defects.

SUBMITTER: Carracedo S

PROVIDER: S-EPMC3668281 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Publications

Expression pattern of protein kinase C ϵ during mouse embryogenesis.

Carracedo Sergio S Braun Ursula U Leitges Michael M

BMC developmental biology 20130502

<h4>Background</h4>Protein kinase C epsilon (PKCϵ) belongs to the novel PKC subfamily, which consists of diacylglycerol dependent- and calcium independent-PKCs. Previous studies have shown that PKCϵ is important in different contexts, such as wound healing or cancer. In this study, we contribute to expand the knowledge on PKCϵ by reporting its expression pattern during murine midgestation using the LacZ reporter gene and immunostaining procedures.<h4>Results</h4>Sites showing highest PKCϵ expres ...[more]

PMID: 23639204

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