Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC2597058 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Li Lei L Baibakov Boris B Dean Jurrien J
Developmental cell 20080901 3
We have identified a subcortical maternal complex (SCMC) that assembles during oocyte growth and is essential for zygotes to progress beyond the first embryonic cell divisions. At least four maternally encoded proteins contribute to this MDa complex: FLOPED, MATER, and TLE6 interact with each other while Filia binds independently to MATER. Although the transcripts encoding these proteins are degraded during meiotic maturation and ovulation, the SCMC proteins persist in the early embryo. The SCMC ...[more]