Ontology highlight
ABSTRACT:
SUBMITTER: Akk AM
PROVIDER: S-EPMC2597084 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20080301 5
The role of innate immunity in the pathogenesis of asthma is unclear. Although increased presence of neutrophils is associated with persistent asthma and asthma exacerbations, how neutrophils participate in the pathogenesis of asthma remains controversial. In this study, we show that the absence of dipeptidyl peptidase I (DPPI), a lysosomal cysteine protease found in neutrophils, dampens the acute inflammatory response and the subsequent mucous cell metaplasia that accompanies the asthma phenoty ...[more]