Ontology highlight
ABSTRACT:
SUBMITTER: Yu Y
PROVIDER: S-EPMC3327800 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Yu Yongxin Y Song Chunying C Zhang Qiongyi Q DiMaggio Peter A PA Garcia Benjamin A BA York Autumn A Carey Michael F MF Grunstein Michael M
Molecular cell 20120301 1
Histone modifications play important roles in regulating DNA-based biological processes. Of the modified sites, histone H3 lysine 56 (H3K56) is unique in that it lies within the globular core domain near the entry-exit sites of the nucleosomal DNA superhelix and its acetylation state in yeast is a marker for newly synthesized histones in transcription, DNA repair, and DNA replication. We now report the presence of H3K56 monomethylation (H3K56me1) in mammalian cells and find that the histone lysi ...[more]