Ontology highlight
ABSTRACT:
SUBMITTER: Barbash O
PROVIDER: S-EPMC2597358 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Barbash Olena O Zamfirova Petia P Lin Douglas I DI Chen Xiangmei X Yang Ke K Nakagawa Hiroshi H Lu Fengmin F Rustgi Anil K AK Diehl J Alan JA
Cancer cell 20080701 1
SCF(Fbx4) was recently identified as the E3 ligase for cyclin D1. We now describe cell-cycle-dependent phosphorylation and dimerization of Fbx4 that is regulated by GSK3beta and is defective in human cancer. We present data demonstrating that a pathway involving Ras-Akt-GSK3beta controls the temporal phosphorylation and dimerization of the SCF(Fbx4) E3 ligase. Inhibition of Fbx4 activity results in accumulation of nuclear cyclin D1 and oncogenic transformation. The importance of this regulatory ...[more]