Ontology highlight
ABSTRACT:
SUBMITTER: Josephsohn NS
PROVIDER: S-EPMC2597397 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Organic letters 20050601 13
[reaction: see text] A readily available iso-leucine-based phosphine ligand is used to promote Ag-catalyzed Mannich reactions between silylketene acetals and various alkynyl imines. Reactions can be effected in the presence of 5 mol % catalyst, without the need for rigorous exclusion of air, and with commercially available solvents (without purification) to afford the desired beta-alkynyl-beta-amino esters in 84-94% ee and 61-91% isolated yield. ...[more]