Ontology highlight
ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC5072400 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20160909 37
We have developed a new class of cinchonium betaine catalysts bearing both a base moiety and an aromatic moiety as an N-substituent of the quinuclidine motif. These cinchonium betaines were found to promote proton transfer catalysis with 1000-5000 turnovers per 24 h, thereby enabling us to realize highly efficient enantioselective isomerization of trifluoromethyl imines to provide a practical access to optically active trifluoromethylated amines. ...[more]