Single molecule nanometronome.
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ABSTRACT:
SUBMITTER: Buranachai C
PROVIDER: S-EPMC2597577 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Publications
Single molecule nanometronome.
Buranachai Chittanon C McKinney Sean A SA Ha Taekjip T
Nano letters 20060301 3
We constructed a DNA-based nanomechanical device called the nanometronome. Our device is made by introducing complementary single-stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the sticky end. Since the device displays clearly distinguishable responses even with a single base pair difference, it may lead to a single molecule sens ...[more]
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