Angiotensin II causes endothelial-dependent increase in expression of Ca(V)1.2 protein in cultured arteries.
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ABSTRACT:
SUBMITTER: Wang WZ
PROVIDER: S-EPMC2600590 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
Angiotensin II causes endothelial-dependent increase in expression of Ca(V)1.2 protein in cultured arteries.
Wang Wen-Ze WZ Pang Li L Palade Philip P
European journal of pharmacology 20080930 1-3
Examination was made of the direct vascular effects of the hypertension-inducing pressor hormone angiotensin II on expression and activity of the voltage-gated calcium channel Ca(V)1.2. Freshly dissected rat superior mesenteric artery beds were maintained in organ culture unpressurized for 24 h in the presence or absence of angiotensin II. Relative to controls, angiotensin II increased Ca(V)1.2 protein expression and tension-inducing activity but not Ca(V)1.2 message. The increase in Ca(V)1.2 pr ...[more]
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