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Endothelium-specific amyloid precursor protein deficiency causes endothelial dysfunction in cerebral arteries.


ABSTRACT: The exact physiological function of amyloid-? precursor protein (APP) in endothelial cells is unknown. Endothelium-specific APP-deficient (eAPP-/-) mice were created to gain new insights into the role of APP in the control of vascular endothelial function. Endothelium-dependent relaxations to acetylcholine were significantly impaired in basilar arteries of global APP knockout (APP-/-) and eAPP-/- mice ( P?

SUBMITTER: d'Uscio LV 

PROVIDER: S-EPMC6168907 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Endothelium-specific amyloid precursor protein deficiency causes endothelial dysfunction in cerebral arteries.

d'Uscio Livius V LV   He Tongrong T   Santhanam Anantha V AV   Katusic Zvonimir S ZS  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20170929 10


The exact physiological function of amyloid-β precursor protein (APP) in endothelial cells is unknown. Endothelium-specific APP-deficient (eAPP<sup>-/-</sup>) mice were created to gain new insights into the role of APP in the control of vascular endothelial function. Endothelium-dependent relaxations to acetylcholine were significantly impaired in basilar arteries of global APP knockout (APP<sup>-/-</sup>) and eAPP<sup>-/-</sup> mice ( P < 0.05). In contrast, endothelium-independent relaxations  ...[more]

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