Endothelium-specific amyloid precursor protein deficiency causes endothelial dysfunction in cerebral arteries.
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ABSTRACT:
SUBMITTER: d'Uscio LV
PROVIDER: S-EPMC6168907 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Endothelium-specific amyloid precursor protein deficiency causes endothelial dysfunction in cerebral arteries.
d'Uscio Livius V LV He Tongrong T Santhanam Anantha V AV Katusic Zvonimir S ZS
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20170929 10
The exact physiological function of amyloid-β precursor protein (APP) in endothelial cells is unknown. Endothelium-specific APP-deficient (eAPP<sup>-/-</sup>) mice were created to gain new insights into the role of APP in the control of vascular endothelial function. Endothelium-dependent relaxations to acetylcholine were significantly impaired in basilar arteries of global APP knockout (APP<sup>-/-</sup>) and eAPP<sup>-/-</sup> mice ( P < 0.05). In contrast, endothelium-independent relaxations ...[more]
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