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Live cell surface labeling with fluorescent Ag nanocluster conjugates.

ABSTRACT: DNA-encapsulated silver clusters are readily conjugated to proteins and serve as alternatives to organic dyes and semiconductor quantum dots. Stable and bright on the bulk and single molecule levels, Ag nanocluster fluorescence is readily observed when staining live cell surfaces. Being significantly brighter and more photostable than organics and much smaller than quantum dots with a single point of attachment, these nanomaterials offer promising new approaches for bulk and single molecule biolabeling.

SUBMITTER: Yu J

PROVIDER: S-EPMC2600602 | biostudies-literature | 2008 Nov-Dec

REPOSITORIES: biostudies-literature

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Live cell surface labeling with fluorescent Ag nanocluster conjugates.

Yu Junhua J Choi Sungmoon S Richards Chris I CI Antoku Yasuko Y Dickson Robert M RM

Photochemistry and photobiology 20080826 6

DNA-encapsulated silver clusters are readily conjugated to proteins and serve as alternatives to organic dyes and semiconductor quantum dots. Stable and bright on the bulk and single molecule levels, Ag nanocluster fluorescence is readily observed when staining live cell surfaces. Being significantly brighter and more photostable than organics and much smaller than quantum dots with a single point of attachment, these nanomaterials offer promising new approaches for bulk and single molecule biol ...[more]

PMID: 18764887

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