Ontology highlight
ABSTRACT:
SUBMITTER: Beaufays J
PROVIDER: S-EPMC2600610 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Beaufays Jérôme J Adam Benoît B Menten-Dedoyart Catherine C Fievez Laurence L Grosjean Amélie A Decrem Yves Y Prévôt Pierre-Paul PP Santini Sébastien S Brasseur Robert R Brossard Michel M Vanhaeverbeek Michel M Bureau Fabrice F Heinen Ernst E Lins Laurence L Vanhamme Luc L Godfroid Edmond E
PloS one 20081219 12
<h4>Background</h4>During their blood meal, ticks secrete a wide variety of proteins that can interfere with their host's defense mechanisms. Among these proteins, lipocalins play a major role in the modulation of the inflammatory response.<h4>Methodology/principal findings</h4>We previously identified 14 new lipocalin genes in the tick Ixodes ricinus. One of them codes for a protein that specifically binds leukotriene B4 with a very high affinity (Kd: +/-1 nM), similar to that of the neutrophil ...[more]