Multiplex protein assays based on real-time magnetic nanotag sensing.
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ABSTRACT:
SUBMITTER: Osterfeld SJ
PROVIDER: S-EPMC2602607 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
Multiplex protein assays based on real-time magnetic nanotag sensing.
Osterfeld Sebastian J SJ Yu Heng H Gaster Richard S RS Caramuta Stefano S Xu Liang L Han Shu-Jen SJ Hall Drew A DA Wilson Robert J RJ Sun Shouheng S White Robert L RL Davis Ronald W RW Pourmand Nader N Wang Shan X SX
Proceedings of the National Academy of Sciences of the United States of America 20081212 52
Magnetic nanotags (MNTs) are a promising alternative to fluorescent labels in biomolecular detection assays, because minute quantities of MNTs can be detected with inexpensive giant magnetoresistive (GMR) sensors, such as spin valve (SV) sensors. However, translating this promise into easy to use and multilplexed protein assays, which are highly sought after in molecular diagnostics such as cancer diagnosis and treatment monitoring, has been challenging. Here, we demonstrate multiplex protein de ...[more]
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