Dataset Information

A double dissociation in the roles of serotonin and mood in healthy subjects.

ABSTRACT: BACKGROUND:Affective disorders are associated with altered cognitive performance. However, the precise interaction between affect and cognition is unclear. The manipulation of serotonin (5-HT), a neurotransmitter implicated in affect, influences performance on "hot" cognitive tasks that require the processing of affective stimuli, but manipulation of affect via mood induction influences performance on "cold" cognitive tasks that do not involve affective stimuli. We attempted to disentangle the influence of affect on cognition by examining the effect of manipulating both serotonin (via acute tryptophan depletion [ATD]) and mood on established hot and cold cognitive tasks. METHODS:In a double blind, placebo-controlled crossover design, 33 healthy mood-induced (positive, negative, or neutral) subjects completed the (hot) affective go/no-go (AGNG) and (cold) one touch tower (OTT) following both placebo and ATD. RESULTS:Mood influenced performance on the OTT but not AGNG; ATD influenced performance on the AGNG but not OTT. CONCLUSIONS:A double dissociation was demonstrated between the influence of ATD and mood on cognition, indicating that serotonin and mood are not closely linked. We hypothesize that this is due to the differences between emotions and moods and that aberrant cognition in affective disorders may be provoked through both bottom-up and top-down mechanisms.

SUBMITTER: Robinson OJ

PROVIDER: S-EPMC2602857 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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A double dissociation in the roles of serotonin and mood in healthy subjects.

Robinson Oliver J OJ Sahakian Barbara J BJ

Biological psychiatry 20081108 1

<h4>Background</h4>Affective disorders are associated with altered cognitive performance. However, the precise interaction between affect and cognition is unclear. The manipulation of serotonin (5-HT), a neurotransmitter implicated in affect, influences performance on "hot" cognitive tasks that require the processing of affective stimuli, but manipulation of affect via mood induction influences performance on "cold" cognitive tasks that do not involve affective stimuli. We attempted to disentang ...[more]

PMID: 18996509

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Project description:Electroencephalography (EEG) measures the brain's electrophysiological spatio-temporal activities with high temporal resolution. Multichannel and broadband analysis of EEG signals is referred to as EEG microstates (EEG-ms) and can characterize such dynamic neuronal activity. EEG-ms have gained much attention due to the increasing evidence of their association with mental activities and large-scale brain networks identified by functional magnetic resonance imaging (fMRI). Spatially independent EEG-ms are quasi-stationary topographies (e.g., stable, lasting a few dozen milliseconds) typically classified into four canonical classes (microstates A through D). They can be identified by clustering EEG signals around EEG global field power (GFP) maxima points. We examined the EEG-ms properties and the dynamics of cohorts of mood and anxiety (MA) disorders subjects (n = 61) and healthy controls (HCs; n = 52). In both groups, we found four distinct classes of EEG-ms (A through D), which did not differ among cohorts. This suggests a lack of significant structural cortical abnormalities among cohorts, which would otherwise affect the EEG-ms topographies. However, both cohorts' brain network dynamics significantly varied, as reflected in EEG-ms properties. Compared to HC, the MA cohort features a lower transition probability between EEG-ms B and D and higher transition probability from A to D and from B to C, with a trend towards significance in the average duration of microstate C. Furthermore, we harnessed a recently introduced theoretical approach to analyze the temporal dependencies in EEG-ms. The results revealed that the transition matrices of MA group exhibit higher symmetrical and stationarity properties as compared to HC ones. In addition, we found an elevation in the temporal dependencies among microstates, especially in microstate B for the MA group. The determined alteration in EEG-ms temporal dependencies among the cohorts suggests that brain abnormalities in mood and anxiety disorders reflect aberrant neural dynamics and a temporal dwelling among ceratin brain states (i.e., mood and anxiety disorders subjects have a less dynamicity in switching between different brain states).

Project description:Recent actions can benefit or disrupt our current actions and the prefrontal cortex (PFC) is thought to play a major role in the regulation of these actions before they occur. The left PFC has been associated with overcoming interference from past events in the context of language production and working memory. The right PFC, and especially the right IFG, has been associated with preparatory inhibition processes. But damage to the right PFC has also been associated with impairment in sustaining actions in motor intentional disorders. Moreover, bilateral dorsolateral PFC has been associated with the ability to maintain task-sets, and improve the performance of current actions based on previous experience. However, potential hemispheric asymmetries in anticipatory regulation of action have not yet been delineated. In the present study, patients with left (n=7) vs. right (n=6) PFC damage due to stroke and 14 aged- and education-matched controls performed a picture naming and a verbal Simon task (participants had to say "right" or "left" depending on the color of the picture while ignoring its position). In both tasks, performance depended on the nature of the preceding trial, but in different ways. In the naming task, performance decreased if previous pictures were from the same rather than from different semantic categories (i.e., semantic interference effect). In the Simon task, performance was better for both compatible (i.e., response matching the position of the stimulus) and incompatible trials when preceded by a trial of the same compatibility (i.e. Gratton effect) relative to sequential trials of different compatibility. Left PFC patients were selectively impaired in picture naming; they had an increased semantic interference effect compared to both right PFC patients and aged-matched controls. Conversely, right PFC patients were selectively impaired in the Simon task compared to controls or left PFC patients; they showed no benefit when sequential trials were compatible (cC vs. iC trials) or a decreased Gratton effect. These results provide evidence for a double dissociation between left and right PFC in the anticipatory regulation of action. Our results are in agreement with a preponderant role of the left PFC in overcoming proactive interference from competing memory representations and provide evidence that the right PFC, plays a role in sustaining goal-directed actions consistent with clinical data in right PFC patients with motor intentional disorders.

Dataset Information

A double dissociation in the roles of serotonin and mood in healthy subjects.

Publications

A double dissociation in the roles of serotonin and mood in healthy subjects.

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